The rigorous, interdisciplinary research programs at the USC Chan Division of Occupational Science and Occupational Therapy, including previous projects, have cumulatively received more than $25 million of federal funding during the past 20 years. Even more importantly, our research agenda pursues—and generates—knowledge with relevant outcomes for real-world interventions that improve human health, quality of life and well-being.
The Division’s portfolio includes research grants, training grants and contracts. Projects currently within their active funding period are below.
Sensory Adapted Dental Environments to Enhance Oral Care for Children (SADE-2 Study)
Principal Investigator: Sharon A. Cermak
Funding Source: National Institute of Dental and Craniofacial Research
Project Period: 5/1/15 – 4/30/20
Award Number: 1 U01 DE024978-01
Total Award: $3,139,788
Goals: This randomized controlled trial of 220 children—110 of which who have autism spectrum disorders (ASD)—will test an intervention that alters the sensory characteristics of the dental environment in order to decrease children’s physiological anxiety and negative responses during oral care and contribute to increased child comfort as well as safer, more efficient, and less costly dental treatment. If successful, this intervention has the potential to revolutionize clinic-based dental care for the growing population of children with ASD, as well as for typically developing children with dental anxiety and/or sensory over-responsivity.
The Neurobiological Basis of Heterogeneous Social and Motor Deficits in ASD
Principal Investigator: Lisa Aziz-Zadeh
Funding Source: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Project Period: 4/1/15 – 1/31/20
Award Number: 1R01 HD079432-01A1
Total Award: $2,156,234 (subject to change based on subsequent NOAs)
Goals: To better understand the relationship between variation in autism spectrum disorder (ASD) along both social and motor dimensions by showing how these variations, using functional MRI imaging, relate to functioning in social and motor brain networks and functional connectivity between them.
Vertical Integration and Care Coordination in Post-Acute Care Markets
Principal Investigator: Neeraj Sood (USC School of Pharmacy)
Co-Investigator: Natalie Leland
Funding Source: National Institute on Aging
Project Period: 6/15/14 – 4/30/18
Award Number: 1R01AG046838
Awarded To Date: $697,576
Goals: This study will seek to understand how health outcomes and costs of Medicare beneficiaries are influenced by the level of integration between the acute care hospital and PAC provider. We will also examine the potential effects of proposed Medicare reforms aimed at improving care coordination between acute care hospitals and PAC providers.
Diabetes Self-Management Lifestyle Intervention for Urban Minority Young Adults
Principal Investigator: Elizabeth Pyatak
Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Project Period: 7/15/14 – 4/30/17
Award Number: NIH/K01DK099202
Total Award: $456,312
Mentors: Anne Peters, Donna Spruijt-Metz, Robin Whittemore
Goal: This three-year mentored career development award will pilot-test an innovative intervention, Resilient, Empowered, Active Living with Diabetes (REAL), targeting underserved minority young adults with poorly-controlled diabetes. The individually tailored, community-based intervention merges findings of an in-depth needs assessment, principles of an evidence-based occupational therapy intervention (Lifestyle Redesign®) and evidence-based diabetes self-management strategies. A proof-of-concept study demonstrated that REAL is feasible to implement, acceptable to young adults with type 1 diabetes and type 2 diabetes, and has potential to produce positive changes in diabetes self-care and glycemic control. The study will randomize 80 young adults with diabetes to receive either the six-month REAL intervention or an attention control condition. Blinded data collectors will assess glycemic control, diabetes self-care behaviors and quality of life outcomes, as well as potential intervention mediators, before and after the six-month intervention. Additionally, a rigorous process evaluation will be executed to evaluate intervention implementation and study procedures. It is anticipated that findings from this pilot study will be used to inform a large-scale randomized controlled trial of the REAL intervention.
Integrating Childhood Obesity Prevention into Home Visitation Programs
Principal Investigator: Sarah-Jeanne Salvy
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI): Community-Based Health Intervention Pilot Project Program
Project Period: 7/1/14 – 6/30/15
Award Number: SC CTSI (NIH/NCATS) #8UL1TR000130
Total Award: $27,686
Collaborators: Titus Galama, Antelope Valley Partners for Health
Goal: This translational study will assess the feasibility, initial efficacy and cost-benefit of delivering a nutrition and physical activity module, named COPE (Childhood Obesity Prevention at homE) to an established Home Visitation Program (HVP) curriculum. Home visitation programs provide in-home services to low-income mothers and their children, and address multiple areas of mother and child health, but they have yet to be tested as an effective infrastructure for obesity prevention in early childhood. This nine-month pilot study will be conducted in partnership with an established HVP in Antelope Valley (Calif.), and will provide the feasibility data required to secure funding from NIH to test the long-term implementation of COPE on early childhood obesity prevention.
Effects of Mind-Body Interventions on Stress, Anxiety, and Pain in Hand Therapy Patients
Principal Investigator: Shawn Roll
Funding Source: American Society of Hand Therapists
Project Period: 6/1/14 – 5/31/15
Total Award: $3,135
Collaborators: David Black, Janice Rocker, Aimee Aguillon
Goal: This cross-over design study is being conducted to evaluate the proximal effects of mindfulness and visual biofeedback on stress, anxiety and pain in patients receiving hand therapy for hand dysfunction due to an orthopedic injury. Using both qualitative and quantitative techniques, this study will provide foundational information regarding potential short-term outcome measures, as well as tolerability, utility and feasibility necessary to develop an effective integrative mind-body intervention for hand therapy.
Identifying Risk Factors for Harm in Children on Invasive Home Medical Therapies
Co-Principal Investigator: Mary Lawlor
Principal Investigator: Glen Takata
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI) for Multidisciplinary Research Projects
Project Period: 3/15/14 – 6/30/15
Award Number: NIH/NCRR/NCATS #KL2TR00031
Total Award: $45,000
Goal: To conduct a pilot study leading to identifying and understanding the mediators of harm in children on home mechanical ventilation and home parenteral nutrition using systems engineering, human factors approaches and collaborate with parents to reduce harm to their children.
A Smartphone Application to Improve Physical Activity in Underactive Older Adults
K12 Scholar: Stacey Schepens Niemiec
Funding Source: National Institutes of Health, NICHD/NINDS Rehabilitation Research Career Development Program
Project Period: 2013-2016
Award Number: HD055929 (PI: K. Ottenbacher)
Total Award: $75,000
Mentor: Florence Clark
Goal: The immediate purpose of this study is to develop and test a smartphone application that facilitates physical activity engagement and reduces sedentary behavior in underactive older adults. This and future projects will contribute to the long-term goal of developing a complex mobile health intervention that will improve physical activity engagement and overall health in older, at-risk groups and thereby contribute to national healthy aging agendas.
Investigation of the Neural Mechanisms of Sensorimotor Integration
Principal Investigator: Stefanie Bodison
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI) for KL2 Mentoring Research Career Development Award
Project Period: 7/01/13 – 6/30/15
Award Number: NIH/NCRR/NCATS #KL2TR00031
Total Award: $128,152
Mentors: Elizabeth Sowell, Terence D. Sanger, Florence Clark, Stewart Mostofsky
Goal: Using structural MRI, diffusion tensor imaging, and fMRI techniques, this study seeks to investigate the structural and functional connectivity of sensorimotor integration in typically developing children and those with autism spectrum disorder, aged 6-8 years.
Modulating Motor Behavior by Action Observation and Imitation: Implications for Stroke Rehabilitation
Principal Investigator: Lisa Aziz-Zadeh
Funding Source: The Dana Foundation
Project Period: 1/01/12 – 12/31/15
Award Number: CADF/AZIZ-ZADEH/2012
Total Award: $200,000
Collaborators: Carolee Winstein, Hanna Damasio, and Nerses Sanossian
Goal: Investigators will use MRI and fMRI imaging to examine whether, and how best, the mirror neuron system can be activated following stroke to optimally tailor stroke rehabilitation for individual patients.
Sensory Adapted Dental Environments to Enhance Oral Care for Children with Autism
Principal Investigator: Sharon Cermak
Funding Source: National Institute of
Dental and Craniofacial Research
Project Period: 9/15/11 – 8/31/15
Award Number: 1 R34 DE022263-01
Total Award: $531,376
Co-Investigators: USC: Jose Polido, Marian Williams, Michael Dawson, Christianne Lane
Consultants: USC: Joel Hay; Beit Issie Shapiro (Israel): Michele Shapiro
Goal: The goal of this project is to collect information that will support a later clinical trial on the effectiveness of a specially adapted dental environment for children, including children with autism spectrum disorders (ASD) and typically developing children, who have difficulty tolerating oral care in the dental clinic.
Project Director: Florence Clark
Funding Source: NIH Ruth L. Kirschstein National Research Service Award (NRSA); National Institute of Child Health and Human Development - National Center for Medical Rehabilitation Research
Project Period: 5/1/11 – 4/30/16
Award Number: 1T32 HD064578-01A1
Total Award: $1,068,942
Co-Directors: James Gordon, Stanley Azen
Goal: Faculty members from three program branches (occupational therapy, physical therapy, and advanced technology) oversee a coordinated training experience for nine doctoral-level scholars, each over a two-year period, that includes individualized mentorship, core coursework, participation in training seminars, immersion in externally funded projects, and writing of grant proposals and research publications. Anticipated trainee outcomes include an increased capacity to independently conduct randomized controlled trials and an increase in the quantity and rigor of rehabilitation science publications.
MetaNet: A Multilingual Metaphor Extraction, Representation, and Validation System
Project Director: Lisa Aziz-Zadeh
Funding Source: International Computer Science Institute, Berkeley, CA (S. Narayanan, PI)
Project Period: 1/1/12 – 12/31/17
Award Number: 804USC
Contract Amount: $293,273
Abstract: The scope of the USC-led experiment is to conduct a fMRI study on metaphorical language processing and emotion processing to approximately 20 subjects.
Project Director: Florence Clark
Funding Source: Western Psychological Services
Project Period: 6/01/98 – 6/30/15
Contract Amount to Date: $1,238,331
Abstract: Under this contract, the USC Chan Division of Occupational Science and Occupational Therapy provides updates to the teaching materials used in Western Psychological Services’ continuing education program and provides administrative services as related to the program.