University of Southern California
Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy
Redesigning Lives Globally
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Active Grants

Active Grants

The rigorous, interdisciplinary research programs at the USC Chan Division of Occupational Science and Occupational Therapy, including previous projects, have cumulatively received more than $25 million of federal funding during the past 20 years. Even more importantly, our research agenda pursues—and generates—knowledge with relevant outcomes for real-world interventions that improve human health, quality of life and well-being.

The USC Chan Division’s portfolio includes research grants, career development grants, training grants and contracts. Projects currently within their active funding period are below.

Research Grants

Identifying Patient-Centered Fall Prevention Care Process in Hip Fracture Rehabilitation

Principal Investigator: Natalie Leland
Funding Source: Agency for Healthcare Research and Quality
Project Period: 07/01/15 – 06/30/18
Award Number: 1K01HS022907
Total Award: $437,222
Goal: The research objective of this three-year mentored career development award is to address the occurrence of fall rates among post-acute care patients by defining gaps in rehabilitation documentation and practice, developing patient-centered evidence based quality measures of rehabilitation services in the area of fall prevention and better informing opportunities for improving quality of rehabilitation services

Sensory Adapted Dental Environments to Enhance Oral Care for Children (SADE-2 Study)

Principal Investigator: Sharon A. Cermak
Funding Source: National Institute of Dental and Craniofacial Research
Project Period: 5/1/15 – 4/30/20
Award Number: 1 U01 DE024978-01
Total Award: $3,139,788
Goal: This randomized controlled trial of 220 children—110 of which who have autism spectrum disorders (ASD)—will test an intervention that alters the sensory characteristics of the dental environment in order to decrease children’s physiological anxiety and negative responses during oral care and contribute to increased child comfort as well as safer, more efficient, and less costly dental treatment. If successful, this intervention has the potential to revolutionize clinic-based dental care for the growing population of children with ASD, as well as for typically developing children with dental anxiety and/or sensory over-responsivity.

The Neurobiological Basis of Heterogeneous Social and Motor Deficits in ASD

Principal Investigator: Lisa Aziz-Zadeh
Funding Source: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Project Period: 4/1/15 – 1/31/20
Award Number: 1R01 HD079432-01A1
Total Award: $2,156,234 (subject to change based on subsequent NOAs)
Goal: To better understand the relationship between variation in autism spectrum disorder (ASD) along both social and motor dimensions by showing how these variations, using functional MRI imaging, relate to functioning in social and motor brain networks and functional connectivity between them.

Vertical Integration and Care Coordination in Post-Acute Care Markets

Principal Investigator: Neeraj Sood (USC School of Pharmacy)
Co-Investigator: Natalie Leland
Funding Source: National Institute on Aging NIH_Aging_logo
Project Period: 6/15/14 – 4/30/18
Award Number: 1R01AG046838
Awarded To Date: $697,576
Goal: This study will seek to understand how health outcomes and costs of Medicare beneficiaries are influenced by the level of integration between the acute care hospital and PAC provider. We will also examine the potential effects of proposed Medicare reforms aimed at improving care coordination between acute care hospitals and PAC providers.

Diabetes Self-Management Lifestyle Intervention for Urban Minority Young Adults

Principal Investigator: Elizabeth Pyatak
Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Project Period: 7/15/14 – 4/30/17NIH_Diabetes_logo
Award Number: NIH/K01DK099202
Total Award: $456,312
Mentors: Anne Peters, Donna Spruijt-Metz, Robin Whittemore
Goal: This three-year mentored career development award will pilot-test an innovative intervention, Resilient, Empowered, Active Living with Diabetes (REAL), targeting underserved minority young adults with poorly-controlled diabetes. The individually tailored, community-based intervention merges findings of an in-depth needs assessment, principles of an evidence-based occupational therapy intervention (Lifestyle Redesign®) and evidence-based diabetes self-management strategies. A proof-of-concept study demonstrated that REAL is feasible to implement, acceptable to young adults with type 1 diabetes and type 2 diabetes, and has potential to produce positive changes in diabetes self-care and glycemic control. The study will randomize 80 young adults with diabetes to receive either the six-month REAL intervention or an attention control condition. Blinded data collectors will assess glycemic control, diabetes self-care behaviors and quality of life outcomes, as well as potential intervention mediators, before and after the six-month intervention. Additionally, a rigorous process evaluation will be executed to evaluate intervention implementation and study procedures. It is anticipated that findings from this pilot study will be used to inform a large-scale randomized controlled trial of the REAL intervention.

A Smartphone Application to Improve Physical Activity in Underactive Older Adults

K12 Scholar: Stacey Schepens Niemiec
Funding Source: National Institutes of Health, NICHD/NINDS Rehabilitation Research Career Development Program
Project Period: 2013 – 2016
Award Number: HD055929 (PI: K. Ottenbacher)
Total Award: $367,652
Mentor: Florence Clark
Goal: The immediate purpose of this study is to develop and test a smartphone application that facilitates physical activity engagement and reduces sedentary behavior in underactive older adults. This and future projects will contribute to the long-term goal of developing a complex mobile health intervention that will improve physical activity engagement and overall health in older, at-risk groups and thereby contribute to national healthy aging agendas.

Noninvasive Brain Stimulation and Neuroimaging to Characterize and Stimulate Recovery After Stroke

K12 Scholar: Sook-Lei Liew
Funding Source: National Institutes of Health, NICHD/NINDS Rehabilitation Research Career Development Program
Project Period: 2014 – 2016
Award Number: HD055929 (PI: K. Ottenbacher)
Total Award to Date: $257,272
Mentor: Carolee Winstein
Goal: Stroke is a leading cause of adult long-term disability around the world. This research project uses neuroimaging to characterize and identify key neural regions and networks in the brain after stroke that lead to recovery. Noninvasive brain stimulation can then be used to facilitate activity in these key regions in order to enhance motor recovery after stroke. Finally, individual differences in neural patterns of recovery and responsiveness to noninvasive brain stimulation can be studied and provide insight into how we can personalize the most effective treatments for individuals after stroke.

Virtual Reality Intervention as a Home Program for Chronic Stroke

K12 Scholar: Rachel Proffitt
Funding Source: National Institutes of Health, NICHD/NINDS Rehabilitation Research Career Development Program
Project Period: 2014 – 2016
Award Number: HD055929 (PI: K. Ottenbacher)
Total Award to Date: $198,126
Mentor: Florence Clark
Goal: The purpose of this study is to develop a manualized, virtual reality-based home activity intervention for persons with chronic stroke and determine the efficacy of the intervention through a pilot randomized controlled trial. This is a part of the larger vision of research activities that explore the capabilities of novel technologies to enhance the delivery of effective rehabilitation interventions across multiple treatment settings, including the motivational and engaging nature of games and technologies, allowing for rapid realization of direct, translational benefits to rehabilitation consumers.

Identifying Risk Factors for Harm in Children on Invasive Home Medical Therapies

Co-Principal Investigator: Mary LawlorCTSI_logo
Principal Investigator: Glen Takata
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI) for Multidisciplinary Research Projects
Project Period: 3/15/14 – 6/30/16
Award Number: NIH/NCRR/NCATS #KL2TR00031
Total Award: $45,000
Goal: To conduct a pilot study leading to identifying and understanding the mediators of harm in children on home mechanical ventilation and home parenteral nutrition using systems engineering, human factors approaches and collaborate with parents to reduce harm to their children.

Investigation of the Neural Mechanisms of Sensorimotor Integration

Principal Investigator: Stefanie BodisonCTSI_logo
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI) for KL2 Mentoring Research Career Development Award
Project Period: 7/01/13 – 6/30/16
Award Number: NIH/NCRR/NCATS #KL2TR00031
Total Award: $128,152
Mentors: Elizabeth Sowell, Terence D. Sanger, Florence Clark, Stewart Mostofsky
Goal: Using structural MRI, diffusion tensor imaging, and fMRI techniques, this study seeks to investigate the structural and functional connectivity of sensorimotor integration in typically developing children and those with autism spectrum disorder, aged 6-8 years.

Modulating Motor Behavior by Action Observation and Imitation: Implications for Stroke Rehabilitation

Principal Investigator: Lisa Aziz-ZadehDana_logo
Funding Source: The Dana Foundation
Project Period: 1/01/12 – 12/31/15
Award Number: CADF/AZIZ-ZADEH/2012
Total Award: $200,000
Collaborators: Carolee Winstein, Hanna Damasio, and Nerses Sanossian
Goal: Investigators will use MRI and fMRI imaging to examine whether, and how best, the mirror neuron system can be activated following stroke to optimally tailor stroke rehabilitation for individual patients.

Sensory Adapted Dental Environments to Enhance Oral Care for Children with Autism

Principal Investigator: Sharon CermakNIDCR_logo
Funding Source: National Institute of
Dental and Craniofacial Research
Project Period: 9/15/11 – 8/31/15
Award Number: 1 R34 DE022263-01
Total Award: $531,376
Co-Investigators: USC: Jose Polido, Marian Williams, Michael Dawson, Christianne Lane
Consultants: USC: Joel Hay; Beit Issie Shapiro (Israel): Michele Shapiro
Goal: The goal of this project is to collect information that will support a later clinical trial on the effectiveness of a specially adapted dental environment for children, including children with autism spectrum disorders (ASD) and typically developing children, who have difficulty tolerating oral care in the dental clinic.

Training Grants

TREET: Training in Rehabilitation Efficacy and Effectiveness Trials

Project Director: Florence Clark OER
Funding Source: NIH Ruth L. Kirschstein National Research Service Award (NRSA); National Institute of Child Health and Human Development - National Center for Medical Rehabilitation Research
Project Period: 5/1/11 – 4/30/16
Award Number: 1T32 HD064578-01A1 MRRIN_logo
Total Award: $1,068,942
Co-Directors: James Gordon, Stanley Azen
Goal: Faculty members from three program branches (occupational therapy, physical therapy, and advanced technology) oversee a coordinated training experience for nine doctoral-level scholars, each over a two-year period, that includes individualized mentorship, core coursework, participation in training seminars, immersion in externally funded projects, and writing of grant proposals and research publications. Anticipated trainee outcomes include an increased capacity to independently conduct randomized controlled trials and an increase in the quantity and rigor of rehabilitation science publications.


Development of Teaching Material in Support of SIPT

Project Director: Florence ClarkWPS_logo
Funding Source: Western Psychological Services
Project Period: 6/01/98 – 6/30/16
Contract Amount to Date: $1,267,325
Abstract: Under this contract, the USC Chan Division of Occupational Science and Occupational Therapy provides updates to the teaching materials used in Western Psychological Services’ continuing education program and provides administrative services as related to the program.