University of Southern California
University of Southern California
Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy
Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy
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Research
Research

Active Grants

Active Grants

The rigorous, interdisciplinary research programs at the USC Chan Division of Occupational Science and Occupational Therapy, including previous projects, have cumulatively received more than $27 million of federal funding during the past 20 years. Even more importantly, our research agenda pursues—and generates—knowledge with relevant outcomes for real-world interventions that improve human health, quality of life and well-being.

The USC Chan Division’s portfolio includes research grants, career development grants, training grants and contracts. Projects currently within their active funding period are below.

Research Grants

Big Data Neuroimaging to Predict Motor Behavior After Stroke

Principal Investigator: Sook-Lei Liew
Funding Source: American Heart Association
Project Period: 01/1/16 – 12/31/17
Award Number: 16IRG26960017
Total Award: $149,446
Goal: This study will examine the preliminary effectiveness of a novel system that could provide an innovative new way for individuals with severe motor impairments after stroke, who cannot activate motor regions through volitional movement, to train and strengthen neural connections between the brain and muscles of the impaired limb in an evidence-based, motivating, portable, and affordable environment. Future work could build on these advances by modifying this system for home use to make neurorehabilitation training more accessible for those who need it most.

REINVENT: A Closed-Loop VR Neurofeedback System for Motor Recovery after Severe Stroke

Principal Investigator: Sook-Lei Liew
Funding Source: American Heart Association
Project Period: 01/1/16 – 12/31/17
Award Number: 16IRG26960017
Total Award: $149,446
Goal: This study will examine the preliminary effectiveness of a novel system that could provide an innovative new way for individuals with severe motor impairments after stroke, who cannot activate motor regions through volitional movement, to train and strengthen neural connections between the brain and muscles of the impaired limb in an evidence-based, motivating, portable, and affordable environment. Future work could build on these advances by modifying this system for home use to make neurorehabilitation training more accessible for those who need it most.

Sonographic Tissue Morphology in Early Stage Work-Related Median Nerve Pathology

Principal Investigator: Shawn C. Roll
Funding Source: Centers for Disease Control: National Institutes of Occupational Safety and Health
Project Period: 09/30/15 – 09/29/19
Award Number: 1 R01 OH010665-01A1
Total Award: $2,324,186
Goal: Evaluate impacts of intensive hand activity on sonographic measurements of tissue morphology, discomfort and occupational performance in a longitudinal study to develop a predictive model of morphologic progression of pathology and screening techniques for early detection of median nerve injury in the workplace.

Identifying Patient-Centered Fall Prevention Care Process in Hip Fracture Rehabilitation

Principal Investigator: Natalie Leland
Funding Source: Agency for Healthcare Research and Quality
Project Period: 07/01/15 – 06/30/18
Award Number: 1K01HS022907
Total Award: $437,222
Goal: The research objective of this three-year mentored career development award is to address the occurrence of fall rates among post-acute care patients by defining gaps in rehabilitation documentation and practice, developing patient-centered evidence based quality measures of rehabilitation services in the area of fall prevention and better informing opportunities for improving quality of rehabilitation services.

Sensory Adapted Dental Environments to Enhance Oral Care for Children (SADE-2 Study)

Principal Investigator: Sharon A. Cermak
Funding Source: NIH/National Institute of Dental and Craniofacial Research
Project Period: 5/1/15 – 4/30/20
Award Number: 1 U01 DE024978-01
Total Award: $3,139,788
Goal: This randomized controlled trial of 220 children—110 of which who have autism spectrum disorders (ASD)—will test an intervention that alters the sensory characteristics of the dental environment in order to decrease children’s physiological anxiety and negative responses during oral care and contribute to increased child comfort as well as safer, more efficient, and less costly dental treatment. If successful, this intervention has the potential to revolutionize clinic-based dental care for the growing population of children with ASD, as well as for typically developing children with dental anxiety and/or sensory over-responsivity.

The Neurobiological Basis of Heterogeneous Social and Motor Deficits in ASD

Principal Investigator: Lisa Aziz-Zadeh
Funding Source: NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development
Project Period: 4/1/15 – 1/31/20
Award Number: 1R01 HD079432-01A1
Total Award: $2,156,234 (subject to change based on subsequent NOAs)
Goal: To better understand the relationship between variation in autism spectrum disorder (ASD) along both social and motor dimensions by showing how these variations, using functional MRI imaging, relate to functioning in social and motor brain networks and functional connectivity between them.

Vertical Integration and Care Coordination in Post-Acute Care Markets

Principal Investigator: Neeraj Sood (USC School of Pharmacy)
Co-Investigator: Natalie Leland
Funding Source: NIH/National Institute on Aging
Project Period: 6/15/14 – 4/30/18
Award Number: 1R01AG046838
Awarded To Date: $697,576
Goal: This study will seek to understand how health outcomes and costs of Medicare beneficiaries are influenced by the level of integration between the acute care hospital and PAC provider. We will also examine the potential effects of proposed Medicare reforms aimed at improving care coordination between acute care hospitals and PAC providers.

Diabetes Self-Management Lifestyle Intervention for Urban Minority Young Adults

Principal Investigator: Elizabeth Pyatak
Funding Source: NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Project Period: 7/15/14 – 4/30/17
Award Number: NIH/K01DK099202
Total Award: $456,312
Mentors: Anne Peters, Donna Spruijt-Metz, Robin Whittemore
Goal: This three-year mentored career development award will pilot-test an innovative intervention, Resilient, Empowered, Active Living with Diabetes (REAL), targeting underserved minority young adults with poorly-controlled diabetes. The study will randomize 80 young adults with diabetes to receive either the six-month REAL intervention or an attention control condition. Blinded data collectors will assess glycemic control, diabetes self-care behaviors and quality of life outcomes, as well as potential intervention mediators, before and after the six-month intervention. Anticipated findings from this pilot study will be used to inform a large-scale randomized controlled trial of the REAL intervention.

A Smartphone Application to Improve Physical Activity in Underactive Older Adults

K12 Scholar: Stacey Schepens Niemiec
Funding Source: National Institutes of Health, NICHD/NINDS Rehabilitation Research Career Development Program
Project Period: 2013 – 2016
Award Number: HD055929 (PI: K. Ottenbacher)
Total Award: $367,652
Mentor: Florence Clark
Goal: The immediate purpose of this study is to develop and test a smartphone application that facilitates physical activity engagement and reduces sedentary behavior in underactive older adults. This and future projects will contribute to the long-term goal of developing a complex mobile health intervention that will improve physical activity engagement and overall health in older, at-risk groups and thereby contribute to national healthy aging agendas.

Noninvasive Brain Stimulation and Neuroimaging to Characterize and Stimulate Recovery After Stroke

K12 Scholar: Sook-Lei Liew
Funding Source: National Institutes of Health, NICHD/NINDS Rehabilitation Research Career Development Program
Project Period: 2014 – 2016
Award Number: HD055929 (PI: K. Ottenbacher)
Total Award to Date: $257,272
Mentor: Carolee Winstein
Goal: Stroke is a leading cause of adult long-term disability around the world. This research project uses neuroimaging to characterize and identify key neural regions and networks in the brain after stroke that lead to recovery. Noninvasive brain stimulation can then be used to facilitate activity in these key regions in order to enhance motor recovery after stroke. Finally, individual differences in neural patterns of recovery and responsiveness to noninvasive brain stimulation can be studied and provide insight into how we can personalize the most effective treatments for individuals after stroke.

Identifying Risk Factors for Harm in Children on Invasive Home Medical Therapies

Co-Principal Investigator: Mary Lawlor
Principal Investigator: Glen Takata
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI) for Multidisciplinary Research Projects
Project Period: 3/15/14 – 6/30/16
Award Number: NIH/NCRR/NCATS #KL2TR00031
Total Award: $45,000
Goal: To conduct a pilot study leading to identifying and understanding the mediators of harm in children on home mechanical ventilation and home parenteral nutrition using systems engineering, human factors approaches and collaborate with parents to reduce harm to their children.

Investigation of the Neural Mechanisms of Sensorimotor Integration

Principal Investigator: Stefanie Bodison
Funding Source: Keck School of Medicine of USC-Southern California Clinical Translational Science Institute (SC CTSI) for KL2 Mentoring Research Career Development Award
Project Period: 7/01/13 – 6/30/16
Award Number: NIH/NCRR/NCATS #KL2TR00031
Total Award: $128,152
Mentors: Elizabeth Sowell, Terence D. Sanger, Florence Clark, Stewart Mostofsky
Goal: Using structural MRI, diffusion tensor imaging, and fMRI techniques, this study seeks to investigate the structural and functional connectivity of sensorimotor integration in typically developing children and those with autism spectrum disorder, aged 6-8 years.

Modulating Motor Behavior by Action Observation and Imitation: Implications for Stroke Rehabilitation

Principal Investigator: Lisa Aziz-Zadeh
Funding Source: The Dana Foundation
Project Period: 1/01/12 – 6/30/16
Award Number: CADF/AZIZ-ZADEH/2012
Total Award: $200,000
Collaborators: Carolee Winstein, Hanna Damasio and Nerses Sanossian
Goal: Investigators will use MRI and fMRI imaging to examine whether, and how best, the mirror neuron system can be activated following stroke to optimally tailor stroke rehabilitation for individual patients.

Training Grants

TREET: Training in Rehabilitation Efficacy and Effectiveness Trials

Project Director: Florence Clark
Funding Source: NIH Ruth L. Kirschstein National Research Service Award (NRSA); National Institute of Child Health and Human Development - National Center for Medical Rehabilitation Research
Project Period: 5/1/11 – 4/30/16
Award Number: 1T32 HD064578-01A1
Total Award: $1,068,942
Co-Directors: James Gordon, Stanley Azen
Goal: Faculty members from three program branches (occupational therapy, physical therapy, and advanced technology) oversee a coordinated training experience for nine doctoral-level scholars, each over a two-year period, that includes individualized mentorship, core coursework, participation in training seminars, immersion in externally funded projects, and writing of grant proposals and research publications. Anticipated trainee outcomes include an increased capacity to independently conduct randomized controlled trials and an increase in the quantity and rigor of rehabilitation science publications.

Contracts

Development of Teaching Material in Support of SIPT

Project Director: Florence Clark
Funding Source: Western Psychological Services
Project Period: 6/01/98 – 12/31/16
Contract Amount to Date: $1,269,811
Abstract: Under this contract, the USC Chan Division of Occupational Science and Occupational Therapy provides updates to the teaching materials used in Western Psychological Services’ continuing education program and provides administrative services as related to the program.