Home ⟩Research ⟩Active Projects ⟩Characterizing gastrointestinal disorder trajectories for autistic sub-groups: Machine learning prediction of risk profiles and response to treatment

Characterizing gastrointestinal disorder trajectories for autistic sub-groups: Machine learning prediction of risk profiles and response to treatment

SIEFL Core ⟩ DREAmS Lab ⟩

Gastrointestinal (GI) problems are among the most common concern reported by families of autistic children and youth, but efforts to understand the nuances of GI symptoms are stymied by a lack of longitudinal research using real-world clinical datasets. We will use a multimethod, participatory approach to: (1) qualitatively describe autistic people’s GI experiences throughout the lifespan; (2) quantitatively characterize GI symptom rates, presentations, trajectories, and responses to treatment among autistic children/youth using electronic health records (EHRs) from Children’s Hospital Los Angeles (CHLA) (with both structured data, e.g., diagnosis codes and prescriptions; and unstructured data, i.e., keywords extracted from clinical notes via natural language processing); and (3) build predictive models of risk of GI symptom profiles and response to treatment using both traditional and machine learning approaches. By using longitudinal analyses and real-world clinical data, the proposed study provides a more nuanced prediction of GI symptom profiles and response to treatment, and holds promise for informing future targeted interventions to improve care for autistic individuals.

Funding

Type	Source	Number	Amount
Federal	NIH / Eunice Kennedy Shriver National Institute of Child Health & Human Development	R01HD115661	$2,951,222

USC Chan Division of Occupational Science and Occupational Therapy
1540 Alcazar Street, CHP 133, Los Angeles, CA 90089-9003

ACOTE accreditation | NBCOT certification

The USC entry-level master’s degree program (cost of attendance) is fully accredited by the Accreditation Council for Occupational Therapy Education® (ACOTE®) of the American Occupational Therapy Association (AOTA). The USC entry-level doctorate in occupational therapy (OTD) degree program (cost of attendance) has applied for accreditation and has been granted Preaccreditation Status by ACOTE®. View our program’s ACOTE® standards public data. ACOTE® c/o the American Occupational Therapy Association, Inc.®, 7501 Wisconsin Avenue, Suite 510E, Bethesda, MD 20814, (301) 652-AOTA, www.acoteonline.org. The program must complete an on-site evaluation and be granted Accreditation Status before its graduates will be eligible to sit for the national certification examination for the occupational therapist administered by the National Board for Certification in Occupational Therapy, Inc.® (NBCOT®).

Professional program graduates are eligible to apply for certification by National Board for Certification in Occupational Therapy, Inc.® (NBCOT®), nbcot.org. Program results from the NBCOT® can be found online at www.nbcot.org/Educators-Folder/SchoolPerformance.