Faculty / Staff Resources Student Resources
University of Southern California
University of Southern California
USC Chan Division of Occupational Science and Occupational Therapy
USC Chan Division of Occupational Science and Occupational Therapy
X/Twitter Facebook Instagram LinkedIn YouTube
News and Events
News and Events

Study pinpoints three brain regions displaying telltale patterns in autistic individuals
November 14, 2022

USC scientists are first to identify patterns of white matter connectivity exclusive to core autistic symptoms, pointing out potential flaw in previous autism neuroscience research.

Autism Faculty Research

X/Twitter Facebook LinkedIn email

By Mike McNulty

Digital illustration of brain tract maps

Correlational tractography analysis by Aziz-Zadeh and colleagues revealed group differences in multiple tracts throughout the brain. (Courtesy of Lisa Aziz-Zadeh)

New study results from an international research team led by USC scientists have identified a signature pattern of white matter connectivity exclusive to the brains of autistic people distinct from that in the brains of people with developmental coordination disorder (DCD). Their findings were published today in Nature: Scientific Reports.

Approximately 85 percent of autistic people have been, or likely could be, diagnosed with DCD, a condition that makes it relatively more difficult to learn and perform motor skills and activities. DCD can impair everyday occupations such as typing, dressing or walking, which can subsequently diminish one’s social participation and satisfaction.

Distinguishing between the brain activity patterns of autism spectrum disorder (ASD) and DCD populations is critical because the widespread comorbidity of ASD and DCD confounds previous autism research which, at the time it was conducted, was understood to be exclusively investigating its core social–communication symptoms.

“As the scientific community has learned more and more about DCD, we’ve realized that white matter differences previously identified in the autism literature could actually be attributed to this underlying motor comorbidity,” said Lisa Aziz-Zadeh, the study’s senior author. “In fact, that’s exactly what our team found — that many prior research findings are probably not actually reflecting autism’s core symptoms, but are more likely a reflection of co-occurring DCD.”

Lisa Aziz-Zadeh headshot photograph

Associate Professor Lisa Aziz-Zadeh

Aziz-Zadeh is an associate professor at the USC Chan Division of Occupational Science and Occupational Therapy, with joint appointments at the USC Dornsife College of Letters, Arts and Sciences’ Brain and Creativity Institute and the Department of Psychology. She is the director of the USC Center for the Neuroscience of Embodied Cognition, which is managing research projects funded by the National Institutes of Health, U.S. Department of Defense and the Office of the Director of National Intelligence’s Intelligence Advanced Research Projects Activity.

Aziz-Zadeh and colleagues used diffusion weighted MRI, a technique for observing functional brain connectivity, in children and teens from 8 to 17 years old assigned to one of three study groups: those with ASD; those with probable DCD; and typically-developing individuals. The images were analyzed, compared and correlated to motor and social behavior assessments which the participants had also completed.

The researchers found that many structural brain connectivity patterns previously believed to be related to autism also overlap with DCD. Among only the autistic research participants, the team was able to pinpoint three white matter pathways demonstrating distinctly different connectivity, as compared to the DCD and typically developing groups: the longitudinal fibers and u-fibers of the mid-cingulum, the corpus callosum forceps minor/anterior commissure and the left middle cerebellar peduncle. These differences also correlated with autistic participants’ measures of emotional performance and/or autism severity. The brains of children with DCD demonstrated unique white matter patterns in the left cortico-spinal and cortico-pontine tracts.

“These results shows that we can use advanced imaging to distinguish between autism’s hallmark social symptoms and other motor-related symptoms at the level of brain anatomy,” said Emily Kilroy, the publication’s first author and former post-doctoral scholar in Aziz-Zadeh’s lab during the study’s data collection period. “Of course, people are so much more than their brain anatomy, but this degree of clarity and specificity at the anatomical level gets us one step closer to understanding the biological basis and expression of autism.”

The publication’s co-authors include Marzio Gerbella and Giacomo Rizzolatti, faculty at the University of Parma (Italy), and Peter Molfese, staff scientist at the NIH National Institute of Mental Health (Bethesda, Md.). USC imaging scientist Lei Cao, former post-doctoral scholar Laura Harrison and USC Chan occupational science doctoral students Christiana Butera and Aditya Jayashankar were also co-authors.

This publication is part of “The Neurobiological Basis of Heterogeneous Social and Motor Deficits in ASD,” a $2.15 million grant project from the NIH Eunice Kennedy Shriver National Institute of Child Health and Human that ran from 2015-2021 (R01 HD079432-01; PI: Aziz-Zadeh).